The changes in the antioxidant status of heart during experimental hypomagnesemia in balb/c mice
Identifieur interne : 002304 ( Main/Exploration ); précédent : 002303; suivant : 002305The changes in the antioxidant status of heart during experimental hypomagnesemia in balb/c mice
Auteurs : Andrzej Kuzniar [Pologne] ; Piotr Kurys [Pologne] ; Boleslaw Florianczyk [Pologne] ; Stanislawa Szymonik-Lesiuk [Pologne] ; Kazimierz Pasternak [Pologne] ; Marta Stryjecka-Zimmer [Pologne]Source :
- Biometals [ 0966-0844 ] ; 2001-06-01.
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Abstract
Abstract: The present experiment was performed to assess if hypomagnesemia can influence antioxidant status in mice heart. The results could explain possibly a free radical theory of heart damage in magnesium deficiency. We used a rodent model of hypomagnesemia. The magnesium sufficient group received a standard diet whereas a magnesium deficient group received the diet containing a trace amount of magnesium. The activities of the most important antioxidant enzymes – catalase, glutathione peroxidase and superoxide dismutase were assessed in mice heart and liver in a time dependent manner, on the 10th and the 20th day of experiment. The level of magnesium in plasma of animals receiving the magnesium deficient diet dropped twice after the 8th day and four times after the 13th day and then reached a plateau value. The activity of catalase in heart in the magnesium deficient group increased gradually and was significantly (P<0.05) elevated by 27% on the 20th day of experiment whereas the superoxide dismutase activity was significantly decreased by 17% on the 20th day. Glutathione peroxidase activity was insignificantly elevated. The alterations of antioxidant enzyme activities in the heart indicate cardiomyocytes's exposure to oxidative stress, which can be responsible for the cardiac lesions observed during hypomagnesemia.
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DOI: 10.1023/A:1016644223759
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Staszica 4, 20-081, Lublin</wicri:regionArea><wicri:noRegion>Lublin</wicri:noRegion></affiliation></author><author><name sortKey="Stryjecka Zimmer, Marta" sort="Stryjecka Zimmer, Marta" uniqKey="Stryjecka Zimmer M" first="Marta" last="Stryjecka-Zimmer">Marta Stryjecka-Zimmer</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>The Department of Biochemistry and Molecular Biology, The Medical University of Lublin, ul Lubartowska 85, 20-123, Lublin</wicri:regionArea><wicri:noRegion>Lublin</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Biometals</title><title level="j" type="abbrev">Biometals</title><idno type="ISSN">0966-0844</idno><idno type="eISSN">1572-8773</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2001-06-01">2001-06-01</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="127">127</biblScope><biblScope unit="page" to="133">133</biblScope></imprint><idno type="ISSN">0966-0844</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0966-0844</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>antioxidant status</term><term>catalase</term><term>free radicals</term><term>glutathione peroxidase</term><term>heart</term><term>hypomagnesemia</term><term>magnesium</term><term>oxidative stress</term><term>reactive oxygen species</term><term>superoxide dismutase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The present experiment was performed to assess if hypomagnesemia can influence antioxidant status in mice heart. The results could explain possibly a free radical theory of heart damage in magnesium deficiency. We used a rodent model of hypomagnesemia. The magnesium sufficient group received a standard diet whereas a magnesium deficient group received the diet containing a trace amount of magnesium. The activities of the most important antioxidant enzymes – catalase, glutathione peroxidase and superoxide dismutase were assessed in mice heart and liver in a time dependent manner, on the 10th and the 20th day of experiment. The level of magnesium in plasma of animals receiving the magnesium deficient diet dropped twice after the 8th day and four times after the 13th day and then reached a plateau value. The activity of catalase in heart in the magnesium deficient group increased gradually and was significantly (P<0.05) elevated by 27% on the 20th day of experiment whereas the superoxide dismutase activity was significantly decreased by 17% on the 20th day. Glutathione peroxidase activity was insignificantly elevated. The alterations of antioxidant enzyme activities in the heart indicate cardiomyocytes's exposure to oxidative stress, which can be responsible for the cardiac lesions observed during hypomagnesemia.</div></front></TEI><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Kuzniar, Andrzej" sort="Kuzniar, Andrzej" uniqKey="Kuzniar A" first="Andrzej" last="Kuzniar">Andrzej Kuzniar</name></noRegion><name sortKey="Florianczyk, Boleslaw" sort="Florianczyk, Boleslaw" uniqKey="Florianczyk B" first="Boleslaw" last="Florianczyk">Boleslaw Florianczyk</name><name sortKey="Kurys, Piotr" sort="Kurys, Piotr" uniqKey="Kurys P" first="Piotr" last="Kurys">Piotr Kurys</name><name sortKey="Pasternak, Kazimierz" sort="Pasternak, Kazimierz" uniqKey="Pasternak K" first="Kazimierz" last="Pasternak">Kazimierz Pasternak</name><name sortKey="Stryjecka Zimmer, Marta" sort="Stryjecka Zimmer, Marta" uniqKey="Stryjecka Zimmer M" first="Marta" last="Stryjecka-Zimmer">Marta Stryjecka-Zimmer</name><name sortKey="Szymonik Lesiuk, Stanislawa" sort="Szymonik Lesiuk, Stanislawa" uniqKey="Szymonik Lesiuk S" first="Stanislawa" last="Szymonik-Lesiuk">Stanislawa Szymonik-Lesiuk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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